Human Biospecimen Processing and Analyses

CMS area of excellence is Molecular and Cell Biology services for translational science and precision medicine programs, including manipulations with biofluid cellular fractions and tissue components (cells, DNA, RNA, proteins), comprehensive molecular analyses (proteomics, glycoproteomics, genomics) and cell-based assays. As a part of Cureline Group, CMS also provides access to biospecimen acquisition, translational histopathology, human and animal tissue management and proprietary glycoproteomic technology.

Cureline experienced team of life sciences PhDs with translational research biotech and pharma experience and clinical network management MD level experts provides consulting and direct support for our clients’ research programs in translational and precision medicine aiming at biomarker and drug discovery, development of molecular and companion diagnostics (CDx), test validation studies and new product development. We bring to you a broad clinical and scientific expertise:

  • Consulting on biospecimen selection for your project
  • Custom biobanking protocol development
  • Custom research protocol development
  • DNA/RNA/protein isolation from human and animal tissues (fresh, frozen, FFPE, OCT)
  • PBMC/BMMC isolation (normal donors and clinically-defined patients)
  • Biomarker discovery and validation (Proteomics, Genomics, Glycoproteomics)
  • Dissociated Tumor Cells (DTCs) isolation from human tumors and animal models (viable and frozen)
  • Cell types separation from whole blood (human, animal)
    • total peripheral blood mononuclear cells (PBMC)
    • lymphocytes (T cells, B cells, NK cells)
    • monocytes, macrophages, myeloid cells, granulocytes, erythrocytes, platelets and other types
  • Stem/progenitor cells isolation from fresh human lipoaspirate
  • Cell-based assays (cell viability, proliferation, migration, invasion, immuno-oncology assays, etc.)
  • 3D tissue culture and assays (including 3D-histoculture)
  • ELISA, custom protocols
  • Antibody characterization and validation